Peptide Library / Detail
Tripeptide-29
Half-life
Approximately 4-6 hours when applied topically, with variable absorption dependent on formulation vehicle and skin condition
Delivery
Topical application via serums, creams, or transdermal delivery systems
Dosage
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Research Use Only
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Description
Tripeptide-29 is a synthetic three-amino-acid peptide primarily used in dermatological and cosmetic applications for skin rejuvenation and collagen support. It is designed to stimulate fibroblast activity and enhance dermal matrix protein synthesis. This peptide has gained attention in anti-aging formulations for its potential to improve skin firmness and reduce visible signs of aging.
Usage
Typically applied topically in concentrations ranging from 2-5% in serums and creams, applied once or twice daily to clean skin. In research settings, concentrations up to 10% have been studied for enhanced efficacy. Treatment protocols generally recommend continuous use for 8-12 weeks to observe visible improvements in skin texture and firmness.
Mechanism of Action
Tripeptide-29 works by signaling fibroblasts in the dermal layer to increase production of collagen types I and III, as well as other extracellular matrix components such as elastin and fibronectin. The peptide penetrates the stratum corneum and interacts with cellular receptors to upregulate genes associated with structural protein synthesis, promoting dermal remodeling and improved skin architecture.
Benefits(6)
- Stimulates collagen and elastin production in dermal fibroblasts
- Improves skin firmness and elasticity
- Reduces appearance of fine lines and wrinkles
- Enhances overall skin texture and smoothness
- Supports dermal matrix integrity and structural support
- May accelerate wound healing and tissue repair processes
Side Effects(5)
- Mild skin irritation or redness at application site
- Temporary tingling or warmth sensation upon application
- Rare allergic reactions in sensitive individuals
- Potential for contact dermatitis with prolonged use
- Transient dryness or flaking during initial treatment phase