Peptide Library / Detail
Argireline
Half-life
Not applicable for topical cosmetic application
Delivery
Topical application in creams, serums, or advanced delivery systems including polydioxanone bioactive sutures
Dosage
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Description
Argireline (Acetyl Hexapeptide-8) is a synthetic cosmetic peptide designed to reduce the appearance of fine lines and wrinkles through topical application. Often marketed as 'needle-free Botox,' it works by modulating muscle contraction mechanisms in facial skin. It has gained significant public interest as an anti-aging cosmeceutical ingredient.
Usage
Typically applied topically in concentrations ranging from 5-10% in serums, creams, or bioactive delivery systems. Applied once or twice daily to target areas such as forehead, crow's feet, and around the mouth. May be used alone or in combination with other cosmetic procedures including botulinum toxin injections for enhanced results.
Mechanism of Action
Argireline functions as a SNARE complex modulator, interfering with the formation of the protein complex required for neurotransmitter release at the neuromuscular junction. By reducing acetylcholine release, it decreases the intensity of facial muscle contractions, leading to relaxation of expression lines. This mechanism mimics botulinum toxin but through a different, non-toxic pathway suitable for topical application.
Benefits(7)
- Reduction in appearance of fine lines and wrinkles, particularly expression lines
- Non-invasive alternative to botulinum toxin injections
- Synergistic effects when combined with botulinum toxin type-A treatments
- Anti-aging properties through muscle contraction modulation
- Improved skin appearance with regular topical application
- Well-tolerated in cosmetic formulations
- Potential moisturizing and anti-inflammatory effects
Side Effects(5)
- Mild skin irritation or sensitivity in some users
- Potential allergic reactions to peptide formulations
- Variable efficacy between individuals
- Results typically less dramatic than injectable alternatives
- Requires consistent long-term use for maintained effects