Peptide Library / Detail
AHK-Cu
Half-life
Not well-characterized; topical applications show local tissue retention
Delivery
Topical application
Dosage
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Research Use Only
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Description
AHK-Cu is a synthetic tripeptide-copper complex consisting of the amino acid sequence Ala-His-Lys bound to a copper ion. It is studied primarily for its potential effects on hair growth and skin regeneration. The copper-peptide complex is believed to support tissue remodeling and cellular proliferation through various signaling pathways.
Usage
Typically applied topically in research settings at concentrations ranging from 0.1 to 10 μM in hair growth studies. In vitro research protocols commonly use 1-5 μM concentrations for cell culture applications. Application frequency varies by formulation and research objective.
Mechanism of Action
AHK-Cu promotes hair growth through multiple pathways including stimulation of vascular endothelial growth factor (VEGF) expression, enhancement of dermal papilla cell proliferation, and modulation of transforming growth factor-beta (TGF-β) signaling. The copper ion component facilitates enzymatic activities involved in extracellular matrix remodeling and angiogenesis, while the tripeptide sequence provides cellular signaling functions.
Benefits(7)
- Stimulates hair follicle growth and proliferation
- Increases VEGF expression in dermal papilla cells
- Enhances cellular proliferation in hair follicle structures
- Supports angiogenesis around hair follicles
- May improve hair density and thickness
- Promotes extracellular matrix remodeling
- Demonstrates low cytotoxicity in research models
Side Effects(5)
- Potential skin irritation at application site
- Possible allergic reactions in sensitive individuals
- Copper accumulation with excessive use
- Mild erythema or redness
- Localized pruritus or itching