Peptide Library / Detail
Nonapeptide-1
Half-life
Not applicable for topical application
Delivery
Topical application in creams, serums, or advanced nanoparticle delivery systems
Dosage
—
Research Use Only
All products listed are for laboratory research only — not for human consumption. By browsing, you acknowledge these terms.
Purchase
Description
Nonapeptide-1 is a synthetic biomimetic peptide designed to regulate melanin synthesis in skin cells. It functions as a melanocyte-stimulating hormone (MSH) antagonist, helping to reduce hyperpigmentation and even skin tone. This peptide has gained attention in cosmetic dermatology for its skin brightening properties and ability to address photoaging concerns.
Usage
Typically applied topically in cosmetic formulations at concentrations ranging from 0.5% to 2%. Often incorporated into serums, creams, or nanoparticle delivery systems for enhanced penetration. Application is generally twice daily to affected areas for pigmentation concerns, with visible results expected after 4-8 weeks of consistent use.
Mechanism of Action
Nonapeptide-1 acts as a competitive antagonist of melanocyte-stimulating hormone (MSH) at melanocortin receptors, particularly MC1R. By blocking MSH binding, it inhibits the activation of tyrosinase and other melanogenic enzymes, thereby reducing melanin production in melanocytes. This mechanism helps prevent and reverse hyperpigmentation, age spots, and uneven skin tone associated with UV exposure and aging.
Benefits(7)
- Reduces hyperpigmentation and dark spots
- Brightens overall skin tone
- Reverses signs of photoaging from UV exposure
- Inhibits melanin synthesis at the cellular level
- Improves skin clarity and evenness
- Compatible with advanced delivery systems like nanoparticles for enhanced efficacy
- Non-irritating alternative to hydroquinone for skin lightening
Side Effects(4)
- Mild skin irritation in sensitive individuals
- Temporary redness at application site
- Potential dryness with high concentrations
- Rare allergic reactions to peptide formulations