Peptide Library / Detail
Syn-Coll
Half-life
Not applicable for topical application; cellular effects persist 24-48 hours
Delivery
Topical application (serums, creams); some research explores microneedling-enhanced delivery
Dosage
—
Research Use Only
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Description
Syn-Coll is a synthetic tripeptide designed to stimulate collagen production in skin cells. It mimics natural signaling mechanisms that trigger fibroblast activity and extracellular matrix synthesis. Commonly used in topical formulations and cosmeceutical research, it targets age-related decline in dermal collagen density.
Usage
Typically applied topically in concentrations ranging from 0.01% to 0.1% in serum or cream formulations. Research protocols often involve twice-daily application to target areas for periods of 8-12 weeks. Some studies examine combination therapies with other collagen-boosting agents or delivery enhancement techniques.
Mechanism of Action
Syn-Coll functions as a biomimetic peptide that binds to fibroblast receptors, upregulating procollagen type I and type III synthesis through TGF-β pathway activation. It enhances the expression of collagen-related genes and promotes organized extracellular matrix assembly while potentially reducing matrix metalloproteinase activity that degrades existing collagen.
Benefits(6)
- Increased dermal collagen density and synthesis
- Reduction in fine lines and wrinkle depth
- Improved skin firmness and elasticity
- Enhanced dermal thickness and structural integrity
- Accelerated wound healing and tissue repair
- Protection against UV-induced collagen degradation
Side Effects(5)
- Mild skin irritation at application site
- Transient redness or erythema
- Rare allergic reactions in sensitive individuals
- Potential interaction with other active topical ingredients
- Temporary dryness or flaking during initial use