Peptide Library / Detail
Matrixyl
Half-life
Varies by formulation; topical application provides sustained release over several hours
Delivery
Primarily topical application via creams, serums, or transdermal patches
Dosage
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Description
Matrixyl is a synthetic peptide based on the sequence KTTKS (Lys-Thr-Thr-Lys-Ser), often lipidated as palmitoyl-KTTKS. It is widely used in cosmeceutical applications to stimulate collagen synthesis and improve skin appearance. The peptide works by signaling dermal fibroblasts to increase production of extracellular matrix components, making it a popular anti-aging ingredient in topical skincare formulations.
Usage
Typically applied topically in cream, serum, or patch formulations at concentrations ranging from 3-5%. In research settings, Matrixyl has been studied both as a standalone ingredient and in combination with other bioactive compounds. Transdermal patch delivery has shown enhanced wound healing effects compared to conventional cream formulations. Application is typically twice daily for cosmetic anti-aging purposes.
Mechanism of Action
Matrixyl functions as a matrikine-mimetic peptide that activates dermal fibroblasts through TGF-β signaling pathways. The KTTKS sequence mimics a portion of type I procollagen and stimulates fibroblasts to upregulate synthesis of collagen (types I and III), fibronectin, and other extracellular matrix proteins. The N-terminal palmitoylation enhances cellular penetration and bioavailability. Studies demonstrate increased expression of extracellular matrix genes including COL1A1, COL3A1, and FN1 following Matrixyl treatment.
Benefits(7)
- Stimulates type I and type III collagen synthesis in dermal fibroblasts
- Reduces appearance of fine lines and wrinkles through increased extracellular matrix production
- Accelerates wound healing and tissue repair processes
- Improves skin elasticity and firmness
- Enhances dermal fibroblast viability and metabolic activity
- Demonstrates synergistic effects when combined with platelet-rich fibrin or other bioactive compounds
- Shows potential antimicrobial activity when modified with specific functional groups
Side Effects(4)
- Generally well-tolerated with minimal adverse effects reported
- Potential mild skin irritation in sensitive individuals
- Rare allergic reactions to peptide or carrier components
- Possible cytotoxicity at very high concentrations outside therapeutic range