Peptide Library / Detail
Pal-AHK
Half-life
Not well established; topical formulations typically remain active for 8-12 hours
Delivery
Topical application (creams, serums, solutions)
Dosage
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Research Use Only
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Description
Pal-AHK is a lipopeptide consisting of the tripeptide Ala-His-Lys (AHK) conjugated to palmitic acid. The palmitoyl group enhances skin penetration and cellular uptake of the active peptide sequence. It is primarily researched for its effects on collagen synthesis, tissue remodeling, and anti-aging properties in dermal applications.
Usage
Typically applied topically in concentrations ranging from 0.01% to 0.5% in cosmetic formulations. Research protocols often involve daily application to skin for periods of 4-12 weeks. May also be formulated with penetration enhancers or delivery systems to improve bioavailability.
Mechanism of Action
The palmitic acid moiety acts as a lipophilic anchor that facilitates membrane penetration and increases peptide stability. Once internalized, the AHK sequence interacts with fibroblasts to stimulate extracellular matrix protein synthesis, including collagen and elastin. The tripeptide may also modulate growth factor signaling pathways involved in tissue repair and regeneration.
Benefits(6)
- Enhanced collagen synthesis in dermal tissues
- Improved skin elasticity and firmness
- Reduction in appearance of fine lines and wrinkles
- Accelerated wound healing and tissue repair
- Increased cellular uptake compared to non-lipidated peptides
- Potential hair follicle stimulation and growth promotion
Side Effects(4)
- Mild skin irritation or redness at application site
- Potential allergic reactions in sensitive individuals
- Temporary tingling or warmth upon application
- Rare cases of contact dermatitis