Peptide Library / Detail
Pal-AHK
Half-life
Not well established; topical formulations typically remain active for 8-12 hours
Delivery
Topical application (creams, serums, solutions)
Dosage
—
Research Use Only
All products listed are for laboratory research only — not for human consumption. By browsing, you acknowledge these terms.
Purchase
Description
Pal-AHK is a lipopeptide consisting of the tripeptide Ala-His-Lys (AHK) conjugated to palmitic acid. The palmitoyl group enhances skin penetration and cellular uptake of the active peptide sequence. It is primarily researched for its effects on collagen synthesis, tissue remodeling, and anti-aging properties in dermal applications.
Usage
Typically applied topically in concentrations ranging from 0.01% to 0.5% in cosmetic formulations. Research protocols often involve daily application to skin for periods of 4-12 weeks. May also be formulated with penetration enhancers or delivery systems to improve bioavailability.
Mechanism of Action
The palmitic acid moiety acts as a lipophilic anchor that facilitates membrane penetration and increases peptide stability. Once internalized, the AHK sequence interacts with fibroblasts to stimulate extracellular matrix protein synthesis, including collagen and elastin. The tripeptide may also modulate growth factor signaling pathways involved in tissue repair and regeneration.
Benefits(6)
- Enhanced collagen synthesis in dermal tissues
- Improved skin elasticity and firmness
- Reduction in appearance of fine lines and wrinkles
- Accelerated wound healing and tissue repair
- Increased cellular uptake compared to non-lipidated peptides
- Potential hair follicle stimulation and growth promotion
Side Effects(4)
- Mild skin irritation or redness at application site
- Potential allergic reactions in sensitive individuals
- Temporary tingling or warmth upon application
- Rare cases of contact dermatitis
Pal-AHK — frequently asked questions
What is Pal-AHK?
Pal-AHK is a lipopeptide consisting of the tripeptide Ala-His-Lys (AHK) conjugated to palmitic acid. The palmitoyl group enhances skin penetration and cellular uptake of the active peptide sequence. It is primarily researched for its effects on collagen synthesis, tissue remodeling, and anti-aging properties in dermal applications.
What is the half-life of Pal-AHK?
Pal-AHK has an approximate half-life of Not well established; topical formulations typically remain active for 8-12 hours. The half-life determines how often you need to inject to maintain steady blood levels — use the Peptides Calculator half-life calculator to plot your specific dosing schedule and see the decay curve.
How is Pal-AHK administered?
Pal-AHK is typically delivered via topical application (creams, serums, solutions). The Peptides Calculator app helps you reconstitute the vial with bacteriostatic water, calculate your exact dose in syringe units, and track each injection.
How does Pal-AHK work?
The palmitic acid moiety acts as a lipophilic anchor that facilitates membrane penetration and increases peptide stability. Once internalized, the AHK sequence interacts with fibroblasts to stimulate extracellular matrix protein synthesis, including collagen and elastin. The tripeptide may also modulate growth factor signaling pathways involved in tissue repair and regeneration.
What are the researched benefits of Pal-AHK?
Studied benefits of Pal-AHK include: Enhanced collagen synthesis in dermal tissues, Improved skin elasticity and firmness, Reduction in appearance of fine lines and wrinkles, Accelerated wound healing and tissue repair, Increased cellular uptake compared to non-lipidated peptides, Potential hair follicle stimulation and growth promotion. These are research findings only — Peptides Calculator does not provide medical advice; consult a qualified healthcare professional before starting any peptide protocol.
What are the side effects of Pal-AHK?
Reported side effects of Pal-AHK include: Mild skin irritation or redness at application site, Potential allergic reactions in sensitive individuals, Temporary tingling or warmth upon application, Rare cases of contact dermatitis. Always discuss potential side effects with a licensed healthcare provider before using any research peptide.
Related peptides
Other skin/hair compounds in the Peptides Calculator library.
AHK-Cu
Half-life · Not well-characterized; topical applications show local tissue retention
Syn-Coll
Half-life · Not applicable for topical application; cellular effects persist 24-48 hours
Tripeptide-29
Half-life · Approximately 4-6 hours when applied topically, with variable absorption dependent on formulation vehicle and skin condition
Nonapeptide-1
Half-life · Not applicable for topical application
Matrixyl
Half-life · Varies by formulation; topical application provides sustained release over several hours
Argireline
Half-life · Not applicable for topical cosmetic application