Peptide Library / Detail
Syn-AKE
Half-life
Not well characterized for topical application; effects are localized and temporary
Delivery
Topical application in cosmetic formulations
Dosage
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Research Use Only
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Description
Syn-AKE is a synthetic tripeptide (β-Ala-Pro-Dab) designed to mimic the activity of waglerin-1, a component of temple viper venom. It functions as a muscle relaxant peptide primarily used in cosmetic applications for reducing the appearance of expression lines and wrinkles. The peptide acts as a reversible antagonist of muscular nicotinic acetylcholine receptors, providing a topical alternative to neurotoxin injections.
Usage
Typically applied topically in cosmetic formulations at concentrations ranging from 0.5% to 4%. Studies have used 10 μM concentrations for in vitro testing. Application is generally twice daily to areas with expression lines, particularly around the eyes and forehead. Effects are observed within 2-4 weeks of consistent use in research protocols.
Mechanism of Action
Syn-AKE acts as a competitive antagonist at the muscular nicotinic acetylcholine receptor, blocking acetylcholine binding and preventing muscle contraction signals. This temporary muscle relaxation reduces the formation of expression lines. In silico studies demonstrate strong binding affinity to the acetylcholine receptor through hydrogen bonding and hydrophobic interactions, with molecular docking scores indicating favorable binding energy. The peptide modulates neuromuscular junction activity without systemic absorption when applied topically.
Benefits(8)
- Reduces appearance of expression lines and wrinkles
- Provides muscle relaxation effect without injections
- Demonstrates anti-aging activity in in vitro studies
- Shows favorable binding affinity to acetylcholine receptors
- Non-invasive topical application
- Reversible mechanism of action
- Well-tolerated in cosmetic formulations
- May improve skin smoothness and texture
Side Effects(5)
- Potential mild skin irritation at application site
- Possible allergic reactions in sensitive individuals
- Temporary redness or sensitivity
- Effects limited to topical application area
- Rare cases of contact dermatitis