Peptide Library / Detail
Syn-AKE
Half-life
Not well characterized for topical application; effects are localized and temporary
Delivery
Topical application in cosmetic formulations
Dosage
—
Research Use Only
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Description
Syn-AKE is a synthetic tripeptide (β-Ala-Pro-Dab) designed to mimic the activity of waglerin-1, a component of temple viper venom. It functions as a muscle relaxant peptide primarily used in cosmetic applications for reducing the appearance of expression lines and wrinkles. The peptide acts as a reversible antagonist of muscular nicotinic acetylcholine receptors, providing a topical alternative to neurotoxin injections.
Usage
Typically applied topically in cosmetic formulations at concentrations ranging from 0.5% to 4%. Studies have used 10 μM concentrations for in vitro testing. Application is generally twice daily to areas with expression lines, particularly around the eyes and forehead. Effects are observed within 2-4 weeks of consistent use in research protocols.
Mechanism of Action
Syn-AKE acts as a competitive antagonist at the muscular nicotinic acetylcholine receptor, blocking acetylcholine binding and preventing muscle contraction signals. This temporary muscle relaxation reduces the formation of expression lines. In silico studies demonstrate strong binding affinity to the acetylcholine receptor through hydrogen bonding and hydrophobic interactions, with molecular docking scores indicating favorable binding energy. The peptide modulates neuromuscular junction activity without systemic absorption when applied topically.
Benefits(8)
- Reduces appearance of expression lines and wrinkles
- Provides muscle relaxation effect without injections
- Demonstrates anti-aging activity in in vitro studies
- Shows favorable binding affinity to acetylcholine receptors
- Non-invasive topical application
- Reversible mechanism of action
- Well-tolerated in cosmetic formulations
- May improve skin smoothness and texture
Side Effects(5)
- Potential mild skin irritation at application site
- Possible allergic reactions in sensitive individuals
- Temporary redness or sensitivity
- Effects limited to topical application area
- Rare cases of contact dermatitis
Syn-AKE — frequently asked questions
What is Syn-AKE?
Syn-AKE is a synthetic tripeptide (β-Ala-Pro-Dab) designed to mimic the activity of waglerin-1, a component of temple viper venom. It functions as a muscle relaxant peptide primarily used in cosmetic applications for reducing the appearance of expression lines and wrinkles. The peptide acts as a reversible antagonist of muscular nicotinic acetylcholine receptors, providing a topical alternative to neurotoxin injections.
What is the half-life of Syn-AKE?
Syn-AKE has an approximate half-life of Not well characterized for topical application; effects are localized and temporary. The half-life determines how often you need to inject to maintain steady blood levels — use the Peptides Calculator half-life calculator to plot your specific dosing schedule and see the decay curve.
How is Syn-AKE administered?
Syn-AKE is typically delivered via topical application in cosmetic formulations. The Peptides Calculator app helps you reconstitute the vial with bacteriostatic water, calculate your exact dose in syringe units, and track each injection.
How does Syn-AKE work?
Syn-AKE acts as a competitive antagonist at the muscular nicotinic acetylcholine receptor, blocking acetylcholine binding and preventing muscle contraction signals. This temporary muscle relaxation reduces the formation of expression lines. In silico studies demonstrate strong binding affinity to the acetylcholine receptor through hydrogen bonding and hydrophobic interactions, with molecular docking scores indicating favorable binding energy. The peptide modulates neuromuscular junction activity without systemic absorption when applied topically.
What are the researched benefits of Syn-AKE?
Studied benefits of Syn-AKE include: Reduces appearance of expression lines and wrinkles, Provides muscle relaxation effect without injections, Demonstrates anti-aging activity in in vitro studies, Shows favorable binding affinity to acetylcholine receptors, Non-invasive topical application, Reversible mechanism of action, Well-tolerated in cosmetic formulations, May improve skin smoothness and texture. These are research findings only — Peptides Calculator does not provide medical advice; consult a qualified healthcare professional before starting any peptide protocol.
What are the side effects of Syn-AKE?
Reported side effects of Syn-AKE include: Potential mild skin irritation at application site, Possible allergic reactions in sensitive individuals, Temporary redness or sensitivity, Effects limited to topical application area, Rare cases of contact dermatitis. Always discuss potential side effects with a licensed healthcare provider before using any research peptide.
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