Peptide Library / Detail
PTD-DBM
Half-life
Not fully characterized; depends on delivery method
Delivery
Topical application via hydrogel patches or transdermal formulations
Dosage
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Research Use Only
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Description
PTD-DBM is a cell-penetrating peptide designed to inhibit CXXC5, a negative regulator of Wnt/β-catenin signaling. By blocking the interaction between CXXC5 and Dishevelled (Dvl), it promotes activation of Wnt pathways critical for hair follicle regeneration and wound healing. This peptide has shown promise in preclinical research for treating androgenetic alopecia and enhancing tissue repair.
Usage
Typically applied topically in research settings via hydrogel patches or other delivery systems. Experimental protocols have used combination therapy approaches with controlled-release formulations. Dosing and frequency vary by delivery method and remain under investigation in clinical trials.
Mechanism of Action
PTD-DBM contains a protein transduction domain (PTD) fused to a Dishevelled-binding motif (DBM) that competitively inhibits CXXC5 binding to Dishevelled proteins. This inhibition prevents CXXC5 from suppressing Wnt/β-catenin signaling, thereby promoting dermal papilla cell proliferation, hair follicle neogenesis, and enhanced wound healing through reconstruction of the regenerative microenvironment.
Benefits(7)
- Promotes hair follicle regeneration and neogenesis
- Activates Wnt/β-catenin signaling pathways
- Accelerates cutaneous wound healing
- Counteracts DHT-mediated effects in androgenetic alopecia
- Enhances dermal papilla cell proliferation
- Supports reconstruction of regenerative tissue microenvironment
- May improve hair density and thickness in pattern baldness
Side Effects(5)
- Localized skin irritation at application site
- Potential allergic reactions to peptide or delivery vehicle
- Unknown long-term safety profile in humans
- Possible inflammation at treatment area
- Effects on systemic Wnt signaling unknown