Peptide Library / Detail
Leuphasyl
Half-life
Not applicable (topical application with minimal systemic absorption)
Delivery
Topical application in serums, creams, or cosmeceutical formulations
Dosage
—
Research Use Only
All products listed are for laboratory research only — not for human consumption. By browsing, you acknowledge these terms.
Purchase
Description
Leuphasyl (pentapeptide-18) is a synthetic peptide designed to reduce expression wrinkles through a mechanism that modulates neurotransmitter activity at the neuromuscular junction. It acts as an enkephalin analog, mimicking the natural mechanism that helps control muscle contractions in facial expressions. This cosmetic peptide is primarily used in topical anti-aging formulations to reduce the appearance of fine lines and wrinkles, particularly around the eyes and forehead.
Usage
Typically applied topically in concentrations ranging from 0.005% to 0.01% in cosmetic formulations. Applied twice daily to clean skin, focusing on areas with expression lines. Effects are generally observed after 4-8 weeks of consistent use. May be combined with other cosmetic peptides or active ingredients for enhanced anti-aging effects.
Mechanism of Action
Leuphasyl functions as a competitive inhibitor at the acetylcholine receptor site, modulating the release of neurotransmitters involved in muscle contraction. By interfering with the SNARE complex (soluble NSF attachment protein receptor) formation, it reduces the intensity of facial muscle contractions without causing complete paralysis. This leads to a softening of expression lines while maintaining natural facial movement and expressiveness.
Benefits(6)
- Reduces the appearance of expression lines and wrinkles
- Softens forehead lines and crow's feet
- Provides a non-invasive alternative to neurotoxin injections
- Maintains natural facial expressions while reducing wrinkle depth
- Generally well-tolerated with minimal systemic absorption
- Can be combined with other anti-aging actives
Side Effects(4)
- Mild skin irritation at application site
- Transient redness in sensitive individuals
- Rare allergic reactions to peptide components
- Potential reduced efficacy with inconsistent application