Peptide Library / Detail
GHK Basic
Half-life
Less than 1 hour in circulation
Delivery
Topical application or subcutaneous injection
Dosage
—
Research Use Only
All products listed are for laboratory research only — not for human consumption. By browsing, you acknowledge these terms.
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Description
GHK (Gly-His-Lys) is a naturally occurring tripeptide found in human plasma, saliva, and urine that declines with age. It is a copper-binding peptide known for its regenerative and protective properties in skin and tissue repair. GHK has been extensively studied for its role in wound healing, collagen synthesis, and anti-aging applications.
Usage
Research protocols typically involve topical application at concentrations of 0.05-2% in cosmetic formulations, or subcutaneous injection at doses of 1-3 mg per session, 2-3 times weekly. When used systemically, cycles of 4-8 weeks are common with periodic breaks. Topical application is generally performed once or twice daily.
Mechanism of Action
GHK functions by binding copper ions and modulating gene expression related to tissue remodeling and repair. It stimulates collagen and glycosaminoglycan synthesis while promoting angiogenesis and nerve outgrowth. The peptide also demonstrates anti-inflammatory effects by modulating metalloproteinase activity and enhancing antioxidant enzymes, while resetting genes to a more youthful state.
Benefits(8)
- Promotes collagen and elastin production in skin tissue
- Enhances wound healing and tissue repair processes
- Reduces appearance of fine lines and wrinkles
- Improves skin firmness, elasticity, and thickness
- Supports hair growth and follicle health
- Demonstrates anti-inflammatory properties
- Increases antioxidant enzyme activity
- May improve skin clarity and reduce hyperpigmentation
Side Effects(6)
- Mild injection site reactions (redness, swelling)
- Temporary skin irritation with topical application
- Possible metallic taste if administered systemically
- Rare allergic reactions or sensitivity
- Potential copper accumulation with excessive use
- Mild headache in some users