Peptide Library / Detail
Decapeptide-12
Half-life
Not applicable for topical formulations
Delivery
Topical application (creams, serums), dermalinfusion, or microneedle-enhanced delivery
Dosage
—
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Description
Decapeptide-12 is a synthetic oligopeptide consisting of 10 amino acids specifically designed for skin brightening and treatment of hyperpigmentation disorders. It functions as a tyrosinase inhibitor to reduce melanin production without causing cytotoxicity. This peptide has been extensively studied for treating melasma, post-inflammatory hyperpigmentation, and other pigmentation disorders in various skin types.
Usage
Typically formulated in topical skincare products at concentrations of 0.01% to 0.05%. Applied once or twice daily to affected areas. Often combined with chemical exfoliants like 20% glycolic acid or delivered via microneedles or dermalinfusion for enhanced penetration. Treatment duration typically ranges from 8-12 weeks for visible results in melasma and hyperpigmentation.
Mechanism of Action
Decapeptide-12 inhibits tyrosinase enzyme activity, the rate-limiting step in melanin biosynthesis. It interferes with melanogenesis at the cellular level by reducing melanin production in melanocytes without causing cell toxicity. The peptide's mechanism provides a safer alternative to hydroquinone by selectively targeting pigment production while maintaining cell viability. Enhanced delivery methods such as chemical enhancers and microneedles improve skin retention and dermal penetration.
Benefits(7)
- Reduces hyperpigmentation and melasma severity
- Brightens overall skin tone and improves skin luminosity
- Treats post-inflammatory hyperpigmentation effectively
- Safe for use on all skin types including skin of color
- Non-cytotoxic alternative to hydroquinone
- Compatible with combination treatments including glycolic acid
- Demonstrated efficacy in clinical trials for recalcitrant melasma
Side Effects(5)
- Mild irritation at application site
- Temporary redness or erythema
- Dryness or peeling when combined with chemical exfoliants
- Rare allergic reactions or contact dermatitis
- Minimal systemic absorption reduces risk of systemic effects