Peptide Library / Detail
Selank Amidate
Half-life
Unknown; estimated at 20-30 minutes in circulation
Delivery
Intranasal administration or subcutaneous injection
Dosage
—
Research Use Only
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Description
Selank Amidate is a synthetic heptapeptide derivative of tuftsin with an amidated C-terminus, developed in Russia for anxiolytic and nootropic effects. It is designed to enhance learning, memory, and stress resistance while reducing anxiety without sedation. The amidate form features improved stability and bioavailability compared to the original acetate formulation.
Usage
Research protocols typically employ intranasal administration at doses ranging from 250-1000 mcg daily, divided into 2-3 administrations. Studies have examined both acute dosing and chronic administration protocols spanning 7-14 days. The peptide is most commonly administered in the morning and early afternoon to support cognitive function throughout the day.
Mechanism of Action
Selank modulates the expression of brain-derived neurotrophic factor (BDNF) and influences the metabolism of monoamine neurotransmitters including serotonin and dopamine. It stabilizes enkephalins in the bloodstream by inhibiting their enzymatic breakdown, thereby enhancing endogenous opioid system function. The peptide also demonstrates immunomodulatory effects through tuftsin-related mechanisms and influences GABAergic neurotransmission to produce anxiolytic effects without benzodiazepine-like sedation.
Benefits(8)
- Reduces anxiety without sedation or cognitive impairment
- Enhances learning capacity and memory consolidation
- Improves active avoidance conditioning performance (PMID: 14552529, 12449836)
- Supports stress resilience and emotional stability
- Promotes mental clarity and cognitive processing speed
- Demonstrates neuroprotective properties
- Improves attention and concentration
- May enhance immune system function through tuftsin-related activity
Side Effects(6)
- Mild headache (typically transient)
- Nasal irritation with intranasal administration
- Occasional drowsiness at higher doses
- Rare reports of emotional blunting
- Potential for altered sleep patterns
- Mild dizziness in sensitive individuals