Peptide Library / Detail
Vilon
Half-life
Approximately 2-4 hours
Delivery
Subcutaneous or intramuscular injection; oral and topical formulations under investigation
Dosage
—
Research Use Only
All products listed are for laboratory research only — not for human consumption. By browsing, you acknowledge these terms.
Purchase
Description
Vilon is a short bioregulatory dipeptide with the sequence Lys-Glu (KE) that has been studied for its effects on cellular aging, gene expression, and tissue regeneration. Research indicates it may influence epigenetic modifications and regulate key longevity-associated genes in mesenchymal stem cells and various tissues. Originally developed as part of the Khavinson peptide bioregulator family, it has been investigated primarily in gerontological and regenerative medicine contexts.
Usage
Typical research protocols involve subcutaneous or intramuscular administration at doses ranging from 0.5-2 mg per injection, administered 1-2 times daily for cycles of 10-20 days. Some studies have explored oral and topical formulations. Cycles are often repeated with intervals of 1-3 months between treatment periods.
Mechanism of Action
Vilon (KE peptide) acts through epigenetic modulation, specifically regulating the expression of SIRT1, PARP1, and PARP2 genes involved in DNA repair and cellular senescence (PMID: 37782636). It influences mitochondrial function and ribosomal protein expression during cellular aging (PMID: 33342107). The peptide appears to modify chromatin structure in aged cells (PMID: 37042594) and modulates proliferative activity and inflammatory pathways in immune cells (PMID: 35408963), promoting cellular homeostasis and tissue-specific regeneration.
Benefits(8)
- Regulation of longevity-associated genes (SIRT1, PARP1, PARP2)
- Modulation of cellular senescence and aging processes
- Support for mesenchymal stem cell function and differentiation
- Epigenetic modifications that may reverse age-related chromatin changes
- Potential neuroprotective effects and neuronal differentiation support
- Anti-inflammatory effects in monocyte/macrophage cell lines
- Improvement in mitochondrial function during cellular aging
- Potential benefits in dental and periodontal tissue regeneration
Side Effects(5)
- Mild injection site reactions (redness, tenderness)
- Transient fatigue in some research subjects
- Rare allergic responses to peptide formulations
- Limited long-term safety data in human populations
- Potential hormonal interactions not fully characterized