Peptide Library / Detail
N-Acetyl Selank
Half-life
6-8 hours
Delivery
Subcutaneous injection or intranasal spray
Dosage
—
Research Use Only
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Description
N-Acetyl Selank is an acetylated derivative of Selank, a synthetic peptide based on the immunomodulatory peptide tuftsin. The N-acetylation modification extends the peptide's half-life and enhances its stability compared to standard Selank. It is primarily researched for its anxiolytic, nootropic, and mood-regulating properties without sedative or addiction potential.
Usage
Research protocols typically employ 250-1000 mcg administered 1-3 times daily via subcutaneous injection or intranasal spray. Many studies use a 14-30 day cycle with evaluation periods. Administration is often conducted in the morning or early afternoon to support cognitive function throughout the day.
Mechanism of Action
N-Acetyl Selank modulates brain-derived neurotrophic factor (BDNF) expression and influences the enkephalin system to regulate anxiety responses. It affects the balance of serotonin and dopamine while stabilizing IL-6 and other inflammatory markers. The N-acetyl group protects against enzymatic degradation, allowing for enhanced bioavailability and extended activity at GABAergic and monoaminergic receptor sites.
Benefits(7)
- Reduced anxiety without sedation or cognitive impairment
- Enhanced focus and mental clarity
- Improved stress resilience and emotional stability
- Neuroprotective effects and BDNF upregulation
- Enhanced learning and memory consolidation
- Mood stabilization and reduced depression symptoms
- Immunomodulatory effects supporting balanced immune response
Side Effects(6)
- Mild headache in initial dosing period
- Transient fatigue or drowsiness at higher doses
- Nasal irritation with intranasal administration
- Injection site reactions with subcutaneous use
- Rare gastrointestinal discomfort
- Possible initial adjustment period with mood changes