Peptide Library / Detail
Semax Amidate
Half-life
Approximately 30-60 minutes with C-terminal amidation providing enhanced stability
Delivery
Intranasal spray or subcutaneous injection
Dosage
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Research Use Only
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Description
Semax Amidate is a synthetic peptide derived from adrenocorticotropic hormone (ACTH) with enhanced metabolic stability due to C-terminal amidation. It consists of the Met-Glu-His-Phe-Pro-Gly-Pro heptapeptide sequence and has been extensively studied in Russian research for neuroprotective and cognitive-enhancing properties. The amidate form offers improved resistance to enzymatic degradation compared to the standard carboxylic acid form.
Usage
Research protocols typically employ intranasal administration at doses ranging from 300-600 mcg per day, divided into 2-3 applications. Some studies utilize subcutaneous injection at 200-400 mcg daily. Treatment cycles generally span 10-14 days with periodic breaks, though longer protocols up to 60 days have been investigated in metabolic disorder research.
Mechanism of Action
Semax Amidate functions as a melanocortin receptor modulator, influencing brain-derived neurotrophic factor (BDNF) expression and enhancing neurotrophic activity. It modulates enkephalin and serotonergic systems, promotes neuronal survival, and exhibits antioxidant properties. Research indicates involvement in lipid metabolism regulation through modulation of lipid peroxidation processes and membrane phospholipid composition, particularly relevant in metabolic disorders like diabetes mellitus (Elagina et al., 2020).
Benefits(7)
- Enhanced cognitive function and memory consolidation
- Neuroprotective effects against oxidative stress and ischemic damage
- Improved attention span and mental clarity
- Correction of lipid metabolism disorders in diabetic conditions
- Anxiolytic properties without sedation
- Enhanced stress adaptation and resilience
- Potential improvement in cerebral blood flow
Side Effects(6)
- Transient nasal irritation with intranasal administration
- Mild headache in initial dosing period
- Possible overstimulation or restlessness at higher doses
- Sleep disturbances if administered late in the day
- Rare reports of anxiety or jitteriness
- Injection site reactions with subcutaneous delivery