Peptide Library / Detail
N-Acetyl Semax
Half-life
60-90 minutes
Delivery
Intranasal spray or subcutaneous injection
Dosage
—
Research Use Only
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Description
N-Acetyl Semax is an acetylated derivative of the synthetic peptide Semax, which itself is based on a fragment of adrenocorticotropic hormone (ACTH). The N-acetylation modification enhances stability and bioavailability compared to standard Semax. It is primarily researched for its nootropic and neuroprotective properties.
Usage
Research protocols typically involve intranasal administration at doses ranging from 200-600 mcg per day, divided into 2-3 applications. Some research uses subcutaneous injection at 300-1000 mcg daily. Cycles commonly run 14-30 days with breaks between cycles. Best administered in the morning or early afternoon due to potential stimulatory effects.
Mechanism of Action
N-Acetyl Semax modulates brain-derived neurotrophic factor (BDNF) expression and influences the melanocortin system. It affects dopaminergic and serotonergic neurotransmission while providing neuroprotective effects through increased neurotrophin production. The acetyl group enhances blood-brain barrier penetration and metabolic stability, prolonging the peptide's active duration compared to unmodified Semax.
Benefits(7)
- Enhanced cognitive function and mental clarity
- Improved memory formation and recall
- Increased focus and concentration
- Neuroprotective effects against oxidative stress
- Mood elevation and stress resilience
- Enhanced learning capacity
- Potential anxiolytic properties
Side Effects(6)
- Mild headache in some users
- Nasal irritation with intranasal administration
- Possible overstimulation or restlessness
- Sleep disruption if dosed too late in the day
- Mild anxiety in sensitive individuals
- Temporary changes in blood pressure