Peptide Library / Detail
Noopept
Half-life
0.5-1 hour (rapidly metabolized to active cycloprolylglycine metabolite)
Delivery
Oral administration (tablets, capsules), intranasal administration, transdermal microneedle patches (investigational)
Dosage
—
Research Use Only
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Description
Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) is a synthetic nootropic dipeptide developed for cognitive enhancement and neuroprotection. It is structurally related to the racetam family and is reported to have neuroprotective, anxiolytic, and memory-enhancing properties. Research indicates it works through multiple mechanisms including modulation of acetylcholine receptors, HIF-1 activation, and TRPV1 channel inhibition.
Usage
Research protocols typically employ oral dosing at 10-30 mg per day, divided into 1-3 doses. Intranasal administration has been explored in animal models for enhanced bioavailability and direct CNS delivery. Novel delivery systems including transdermal microneedle patches and ultradeformable liposomes are under investigation for once-daily dosing in dementia management. Studies suggest effects may be observed within days to weeks of consistent administration.
Mechanism of Action
Noopept acts through multiple pathways: it modulates α7 nicotinic acetylcholine receptors (α7AChRs) on hippocampal interneurons affecting CA1 pyramidal neuron activity, activates transcription factor HIF-1 which regulates neuroprotective gene expression, inhibits TRPV1 channels reducing oxidative stress and neuropathic pain, and demonstrates DNA protective effects in prediabetic conditions. It appears to enhance NGF and BDNF expression and shows anti-inflammatory and antioxidant properties.
Benefits(8)
- Enhanced cognitive function and memory consolidation
- Neuroprotection against diabetes-induced hippocampal neurotoxicity
- Reduction of neuropathic pain through TRPV1 channel inhibition
- Reversal of parkinsonian pathology in PINK1 knockout models
- Prevention of DNA damage in prediabetic states
- Improvement in amnestic and behavioral disorders
- Protection of ocular, pancreatic, and renal tissue in diabetic models
- Anxiolytic effects and stress reduction
Side Effects(6)
- Headache (reported in some users)
- Irritability or mood changes
- Gastrointestinal discomfort
- Sleep disturbances if taken late in day
- Fatigue or drowsiness in some individuals
- Generally well-tolerated in research studies with minimal adverse effects reported