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PNC-27

p53-Derived HDM2-Targeting Peptide (Investigational)For research use only
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PNC-27 is a synthetic peptide based on residues from the human p53 protein linked to a membrane-penetrating motif. In preclinical research it binds HDM2 localiz…

Half-life

Not well characterized; expected short plasma stability typical of linear peptides (minutes to low hours) without specialized formulation

Delivery

Preclinical studies have explored intratumoral, perilesional, or topical/locoregional administration; systemic delivery remains investigational.

Suggested dosage

Not specified

Usage

Exploratory oncology research to study HDM2-targeted membrane disruption, tumor cell killing, and differential effects between malignant and non-malignant cells.

Mechanism of action

Binds HDM2 on cancer-cell membranes; peptide oligomerization forms transmembrane pores that rapidly disturb ionic gradients and induce necrotic/apoptotic cell death. Selectivity is hypothesized to stem from cancer-specific membrane HDM2 expression.

Benefits (3)

  • Potent cytotoxicity against HDM2-positive cancer cells in vitro
  • Activity reported across multiple tumor cell lines in preclinical studies
  • Mechanistically distinct from DNA-damaging chemotherapeutics

Side effects (3)

  • Local irritation at administration site (preclinical)
  • Potential off-target membrane toxicity/hemolysis at higher concentrations
  • Unknown immunogenicity and systemic safety; not clinically approved
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