Peptide Library / Detail
Mazdutide
Half-life
Approximately 7–10 days (supports once-weekly dosing)
Delivery
Once-weekly subcutaneous injection
Dosage
—
Research Use Only
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Description
Mazdutide (IBI362 / LY3305677) is a once-weekly peptide dual agonist of the GLP-1 receptor and glucagon receptor, derived from the oxyntomodulin scaffold and engineered for prolonged half-life and potent metabolic effects.
Usage
Studied for chronic weight management and metabolic health, including reductions in body weight, waist circumference, liver fat, and improvements in glycemic and cardiometabolic markers.
Mechanism of Action
Co-activates GLP-1R to enhance glucose-dependent insulin secretion, suppress glucagon, slow gastric emptying, and reduce appetite, while GCGR activation increases energy expenditure and promotes lipid mobilization; the combined signaling yields greater weight loss vs. GLP-1–only agonism in studies.
Benefits(4)
- Clinically meaningful body-weight reduction
- Appetite suppression and improved satiety
- Improved glycemic control and cardiometabolic markers
- Reductions in liver fat and waist circumference in trials
Side Effects(5)
- Class-typical GI effects (nausea, vomiting, diarrhea/constipation)
- Decreased appetite
- Injection-site reactions
- Transient increases in pancreatic enzymes (e.g., lipase) reported
- Rare: gallbladder disease or pancreatitis (GLP-1 class consideration)
Mazdutide — frequently asked questions
What is Mazdutide?
Mazdutide (IBI362 / LY3305677) is a once-weekly peptide dual agonist of the GLP-1 receptor and glucagon receptor, derived from the oxyntomodulin scaffold and engineered for prolonged half-life and potent metabolic effects.
What is the half-life of Mazdutide?
Mazdutide has an approximate half-life of Approximately 7–10 days (supports once-weekly dosing). The half-life determines how often you need to inject to maintain steady blood levels — use the Peptides Calculator half-life calculator to plot your specific dosing schedule and see the decay curve.
How is Mazdutide administered?
Mazdutide is typically delivered via once-weekly subcutaneous injection. The Peptides Calculator app helps you reconstitute the vial with bacteriostatic water, calculate your exact dose in syringe units, and track each injection.
How does Mazdutide work?
Co-activates GLP-1R to enhance glucose-dependent insulin secretion, suppress glucagon, slow gastric emptying, and reduce appetite, while GCGR activation increases energy expenditure and promotes lipid mobilization; the combined signaling yields greater weight loss vs. GLP-1–only agonism in studies.
What are the researched benefits of Mazdutide?
Studied benefits of Mazdutide include: Clinically meaningful body-weight reduction, Appetite suppression and improved satiety, Improved glycemic control and cardiometabolic markers, Reductions in liver fat and waist circumference in trials. These are research findings only — Peptides Calculator does not provide medical advice; consult a qualified healthcare professional before starting any peptide protocol.
What are the side effects of Mazdutide?
Reported side effects of Mazdutide include: Class-typical GI effects (nausea, vomiting, diarrhea/constipation), Decreased appetite, Injection-site reactions, Transient increases in pancreatic enzymes (e.g., lipase) reported, Rare: gallbladder disease or pancreatitis (GLP-1 class consideration). Always discuss potential side effects with a licensed healthcare provider before using any research peptide.
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