Peptide Library / Detail
HMG (Human Menopausal Gonadotropin)
Half-life
Approximate: FSH activity ~24–36 hours; LH activity ~10–20 hours (route- and product-dependent).
Delivery
Subcutaneous or intramuscular injection
Dosage
—
Research Use Only
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Description
HMG, also called menotropins, provides both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) bioactivity. In research settings, it’s used to study gametogenesis and steroidogenesis by directly stimulating gonadal FSHR and LHCGR pathways.
Usage
Investigated for inducing follicular development, supporting spermatogenesis, and modeling endocrine feedback in the hypothalamic–pituitary–gonadal (HPG) axis.
Mechanism of Action
FSH component activates FSH receptors in gonadal tissue to promote follicular growth and Sertoli-cell–mediated spermatogenesis. LH component activates LH/CG receptors to stimulate theca/Leydig cell steroidogenesis (estradiol/testosterone).
Benefits(4)
- Stimulates follicular development (ovary)
- Supports spermatogenesis (testis)
- Increases gonadal steroid production
- Useful for HPG-axis functional studies
Side Effects(6)
- Injection-site pain or redness
- Abdominal discomfort/bloating
- Headache or mood changes
- Fluid retention
- Gynecomastia (males)
- Ovarian hyperstimulation–like effects in susceptible models