Peptide Library / Detail
Gonadorelin Acetate (GnRH)
Half-life
Very short plasma half-life (~2–4 minutes IV); functional effect prolonged with SC dosing. Sustained stimulation typically requires pulsatile delivery.
Delivery
IV/SC bolus for stimulation testing; SC pump-based pulsatile infusion (e.g., every 60–120 minutes) for physiologic models; continuous infusion for suppression; intranasal routes appear in some protocols.
Dosage
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Research Use Only
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Description
Gonadorelin is a synthetic decapeptide identical to endogenous GnRH. In research, it’s used to probe and modulate the hypothalamic–pituitary–gonadal (HPG) axis by triggering pituitary release of LH and FSH. Pulsatile delivery mimics physiology and stimulates gonadotropins; continuous exposure desensitizes GnRH receptors and suppresses the axis.
Usage
Employed for LH/FSH stimulation tests, modeling ovulation/spermatogenesis with pulsatile infusion, and creating suppression models (continuous infusion) for endocrine studies.
Mechanism of Action
Binds GnRH receptors on pituitary gonadotropes, activating Gq/11→PLC→IP3/DAG signaling, raising intracellular Ca²⁺ and causing LH/FSH secretion. Pulse frequency/amplitude bias LH vs FSH output; continuous exposure leads to receptor downregulation and decreased gonadotropin release.
Benefits(4)
- Acute LH/FSH surge (diagnostic stimulation)
- Physiologic HPG-axis modeling via pulsatile dosing
- Supports ovulation/spermatogenesis models
- Continuous dosing enables suppression paradigms
Side Effects(5)
- Flushing, headache, nausea, dizziness
- Abdominal discomfort or injection-site irritation
- Transient mood changes or fatigue
- With continuous use: hypoestrogenic/androgen-suppression symptoms (e.g., hot flashes, decreased libido)
- Rare hypersensitivity reactions