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FOX04-DRI (10 mg)

Senolytic PeptideResearch use only

Half-life

Prolonged compared to native FOXO4 peptide (due to retro‑inverso design)

Delivery

Subcutaneous injection (after reconstitution in bacteriostatic water or suitable solvent)

Dosage

Research Use Only

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Description

FOX04‑DRI (Retro‑Inverso) is a synthetic peptide designed to interfere with the FOXO4/p53 interaction, enabling selective induction of apoptosis in senescent cells to improve tissue function and biological age.

Usage

Used in research to remove senescent cells and study aging, tissue regeneration, insulin signaling, and cell cycle control.

Mechanism of Action

Acts as a cell‑penetrating peptide that disrupts FOXO4 binding to p53, freeing p53 to induce apoptosis in senescent cells.

Benefits(4)

  • Selective clearance of senescent cells
  • Improved organ and tissue function
  • Reduced aging‑related inflammatory signaling
  • Enhanced insulin sensitivity and metabolic outcomes

Side Effects(2)

  • Limited human safety data
  • Potential off‑target effects in non‑senescent cells

FOX04-DRI (10 mg) — frequently asked questions

  • What is FOX04-DRI (10 mg)?

    FOX04‑DRI (Retro‑Inverso) is a synthetic peptide designed to interfere with the FOXO4/p53 interaction, enabling selective induction of apoptosis in senescent cells to improve tissue function and biological age.

  • What is the half-life of FOX04-DRI (10 mg)?

    FOX04-DRI (10 mg) has an approximate half-life of Prolonged compared to native FOXO4 peptide (due to retro‑inverso design). The half-life determines how often you need to inject to maintain steady blood levels — use the Peptides Calculator half-life calculator to plot your specific dosing schedule and see the decay curve.

  • How is FOX04-DRI (10 mg) administered?

    FOX04-DRI (10 mg) is typically delivered via subcutaneous injection (after reconstitution in bacteriostatic water or suitable solvent). The Peptides Calculator app helps you reconstitute the vial with bacteriostatic water, calculate your exact dose in syringe units, and track each injection.

  • How does FOX04-DRI (10 mg) work?

    Acts as a cell‑penetrating peptide that disrupts FOXO4 binding to p53, freeing p53 to induce apoptosis in senescent cells.

  • What are the researched benefits of FOX04-DRI (10 mg)?

    Studied benefits of FOX04-DRI (10 mg) include: Selective clearance of senescent cells, Improved organ and tissue function, Reduced aging‑related inflammatory signaling, Enhanced insulin sensitivity and metabolic outcomes. These are research findings only — Peptides Calculator does not provide medical advice; consult a qualified healthcare professional before starting any peptide protocol.

  • What are the side effects of FOX04-DRI (10 mg)?

    Reported side effects of FOX04-DRI (10 mg) include: Limited human safety data, Potential off‑target effects in non‑senescent cells. Always discuss potential side effects with a licensed healthcare provider before using any research peptide.

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