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ARA-290

Non-erythropoietic EPO-Derived PeptideFor research use only
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ARA-290 (cibinetide) is an 11–amino acid peptide engineered from erythropoietin’s helix-B that selectively activates the EPOR–CD131 ‘innate repair receptor’ to…

Half-life

Short (~20 minutes after SC; minutes after IV), with pharmacodynamic effects outlasting plasma exposure

Delivery

Subcutaneous injection (e.g., once daily in 28-day study designs); IV used in early PK work.

Suggested dosage

Not specified

Usage

Studied in small fiber neuropathy (e.g., sarcoidosis-associated and type 2 diabetes), ocular/ischemic injury models, and inflammatory conditions to evaluate symptom relief, nerve fiber regeneration, and improved metabolic/quality-of-life outcomes.

Mechanism of action

Binds the EPOR–CD131 heteroreceptor (innate repair receptor), triggering JAK2/STAT and PI3K/Akt pathways while suppressing NF-κB–mediated inflammation; restores tissue homeostasis and supports small-fiber nerve regrowth.

Benefits (5)

  • Reduces neuropathic pain and autonomic symptoms in SFN studies
  • Improves quality-of-life measures
  • Increases corneal small-fiber nerve density in clinical imaging
  • Anti-inflammatory, cytoprotective effects without erythropoiesis
  • Metabolic improvements noted in type 2 diabetes cohorts

Side effects (3)

  • Generally well tolerated in trials
  • Mild injection-site reactions
  • No meaningful changes in hematocrit/hemoglobin (non-erythropoietic)
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