Peptide Library / Detail
VIP
Half-life
Very short in plasma (~1–2 minutes); effects may be prolonged with localized delivery or protected formulations.
Delivery
Intranasal spray or nebulized/inhaled routes for airway studies; subcutaneous or intravenous bolus/infusion in systemic physiology models.
Dosage
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Research Use Only
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Description
VIP (Vasoactive Intestinal Peptide) is a 28–amino acid neuropeptide widely distributed in the CNS, lungs, and gut. It exerts potent vasodilatory, bronchodilatory, and immunomodulatory effects and is studied for roles in airway tone, mucosal protection, and neuroimmune signaling.
Usage
Research on airway diseases (bronchodilation, mucus regulation), gastrointestinal motility/secretions and barrier function, neuroprotection, and immune modulation (anti-inflammatory, Th2/Treg bias).
Mechanism of Action
Binds VPAC1/VPAC2 (class B GPCRs) to activate Gs→adenylate cyclase→cAMP/PKA signaling, relaxing smooth muscle, enhancing epithelial secretion, and modulating cytokines; rapidly degraded by peptidases (e.g., DPP-IV, neutral endopeptidase).
Benefits(5)
- Bronchodilation and airway smooth-muscle relaxation
- Vasodilation and improved microcirculatory flow
- Reduced pro-inflammatory cytokine signaling
- Support for epithelial barrier integrity and mucus regulation
- Neuroprotective/neuromodulatory effects in CNS models
Side Effects(5)
- Flushing and warmth
- Headache or lightheadedness
- Transient hypotension or tachycardia (dose-dependent)
- Nasal/throat irritation with intranasal or inhaled use
- GI cramping or diarrhea in sensitive subjects