Peptide Library / Detail
MK-677 (Ibutamoren)
Half-life
4-6 hours
Delivery
Oral administration
Dosage
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Research Use Only
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Description
MK-677, also known as ibutamoren, is an orally active growth hormone secretagogue that mimics the action of ghrelin. Unlike traditional peptides, it is a small molecule compound that stimulates the release of growth hormone and IGF-1 without affecting cortisol levels. It has been investigated for applications in growth disorders, muscle wasting, and age-related decline.
Usage
Research protocols typically employ oral dosing of 10-25 mg once daily, usually taken before bed due to potential increases in appetite and to align with natural growth hormone pulsatility. Studies have used continuous administration periods ranging from several weeks to months. Due to its oral bioavailability and extended half-life, once-daily dosing is sufficient.
Mechanism of Action
MK-677 acts as a selective agonist of the growth hormone secretagogue receptor (GHS-R1a), the same receptor activated by the endogenous hormone ghrelin. By binding to GHS-R1a in the hypothalamus and pituitary gland, it stimulates the release of growth hormone, which subsequently increases insulin-like growth factor 1 (IGF-1) production in the liver. This mechanism promotes anabolic effects without directly introducing exogenous growth hormone.
Benefits(7)
- Increased growth hormone and IGF-1 levels
- Enhanced lean body mass and muscle growth
- Improved bone density and skeletal health
- Potential neuroprotective effects and improved neurogenesis
- Increased appetite and nitrogen retention
- Improved sleep quality
- Accelerated recovery and tissue repair
Side Effects(7)
- Increased appetite and potential weight gain
- Water retention and mild edema
- Transient increases in blood glucose and insulin resistance
- Elevated cortisol in some individuals
- Fatigue or lethargy, particularly in early use
- Tingling or numbness in extremities
- Potential impact on cardiovascular markers with long-term use