LL-37

LL-37 — frequently asked questions

• What is LL-37?

  LL-37 (Human Cathelicidin) is the C-terminal, active form of the human cathelicidin (hCAP18). It exhibits broad-spectrum antimicrobial activity and immunomodulatory effects, and is studied for roles in wound repair, biofilm disruption, and epithelial barrier defense.

• What is the half-life of LL-37?

  LL-37 has an approximate half-life of Short; rapidly degraded by proteases (minutes in biological fluids), context-dependent with topical matrices potentially prolonging effect. The half-life determines how often you need to inject to maintain steady blood levels — use the Peptides Calculator half-life calculator to plot your specific dosing schedule and see the decay curve.

• How is LL-37 administered?

  LL-37 is typically delivered via primarily topical or localized/intradermal application in research; formulations often use gels, creams, or hydrogel dressings to improve stability and retention.. The Peptides Calculator app helps you reconstitute the vial with bacteriostatic water, calculate your exact dose in syringe units, and track each injection.

• How does LL-37 work?

  Disrupts microbial membranes via amphipathic helical insertion; modulates TLR signaling and cytokine/chemokine release; promotes keratinocyte migration/angiogenesis and can neutralize LPS to reduce endotoxin-driven inflammation.

• What are the researched benefits of LL-37?

  Studied benefits of LL-37 include: Broad-spectrum antimicrobial and anti-biofilm activity, Supports wound closure and re-epithelialization, Enhances local immune surveillance and barrier function, LPS neutralization and modulation of inflammatory signaling. These are research findings only — Peptides Calculator does not provide medical advice; consult a qualified healthcare professional before starting any peptide protocol.

• What are the side effects of LL-37?

  Reported side effects of LL-37 include: Local irritation, burning, or erythema at application site, Pro-inflammatory effects at higher concentrations, Potential flare of inflammatory dermatoses (e.g., psoriasis models), Rare hypersensitivity reactions. Always discuss potential side effects with a licensed healthcare provider before using any research peptide.