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Vial

LL-37

Host-Defense Antimicrobial PeptideFor research use only
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LL-37 (Human Cathelicidin) is the C-terminal, active form of the human cathelicidin (hCAP18). It exhibits broad-spectrum antimicrobial activity and immunomodula…

Half-life

Short; rapidly degraded by proteases (minutes in biological fluids), context-dependent with topical matrices potentially prolonging effect

Delivery

Primarily topical or localized/intradermal application in research; formulations often use gels, creams, or hydrogel dressings to improve stability and retention.

Suggested dosage

Not specified

Usage

Used in research on chronic wounds, skin/mucosal defense, biofilm-related infections, and innate immunity signaling.

Mechanism of action

Disrupts microbial membranes via amphipathic helical insertion; modulates TLR signaling and cytokine/chemokine release; promotes keratinocyte migration/angiogenesis and can neutralize LPS to reduce endotoxin-driven inflammation.

Benefits (4)

  • Broad-spectrum antimicrobial and anti-biofilm activity
  • Supports wound closure and re-epithelialization
  • Enhances local immune surveillance and barrier function
  • LPS neutralization and modulation of inflammatory signaling

Side effects (4)

  • Local irritation, burning, or erythema at application site
  • Pro-inflammatory effects at higher concentrations
  • Potential flare of inflammatory dermatoses (e.g., psoriasis models)
  • Rare hypersensitivity reactions
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