Peptide Library / Detail
Dulaglutide
Half-life
Approximately ~120 hours (~5 days)
Delivery
Once-weekly subcutaneous injection (prefilled pen formats in clinical use; dose and device vary by study/protocol).
Dosage
—
Research Use Only
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Description
Dulaglutide is a long-acting GLP-1 receptor agonist composed of two GLP-1 analog chains fused to an IgG4 Fc fragment. In research settings it’s used to study glucose homeostasis, gastric emptying, appetite regulation, and cardiometabolic outcomes.
Usage
Investigated for improving glycemic control, reducing cardiometabolic risk markers, and modeling weight/appetite pathways via incretin signaling.
Mechanism of Action
Activates GLP-1 receptors to enhance glucose-dependent insulin secretion, suppress inappropriate glucagon release, slow gastric emptying, and reduce appetite through central and peripheral pathways.
Benefits(4)
- Improved fasting and postprandial glucose
- Reduced A1c in type 2 diabetes models
- Decreased appetite and body weight in study populations
- Potential cardiovascular risk-marker improvements
Side Effects(6)
- Nausea, vomiting, diarrhea, or constipation
- Abdominal pain or decreased appetite
- Injection-site reactions
- Rare: pancreatitis, gallbladder disease
- Hypoglycemia when combined with insulin or sulfonylureas
- Boxed warning (rodent): thyroid C-cell tumors; contraindicated with personal/family history of MTC or MEN2 in clinical use contexts
Dulaglutide — frequently asked questions
What is Dulaglutide?
Dulaglutide is a long-acting GLP-1 receptor agonist composed of two GLP-1 analog chains fused to an IgG4 Fc fragment. In research settings it’s used to study glucose homeostasis, gastric emptying, appetite regulation, and cardiometabolic outcomes.
What is the half-life of Dulaglutide?
Dulaglutide has an approximate half-life of Approximately ~120 hours (~5 days). The half-life determines how often you need to inject to maintain steady blood levels — use the Peptides Calculator half-life calculator to plot your specific dosing schedule and see the decay curve.
How is Dulaglutide administered?
Dulaglutide is typically delivered via once-weekly subcutaneous injection (prefilled pen formats in clinical use; dose and device vary by study/protocol).. The Peptides Calculator app helps you reconstitute the vial with bacteriostatic water, calculate your exact dose in syringe units, and track each injection.
How does Dulaglutide work?
Activates GLP-1 receptors to enhance glucose-dependent insulin secretion, suppress inappropriate glucagon release, slow gastric emptying, and reduce appetite through central and peripheral pathways.
What are the researched benefits of Dulaglutide?
Studied benefits of Dulaglutide include: Improved fasting and postprandial glucose, Reduced A1c in type 2 diabetes models, Decreased appetite and body weight in study populations, Potential cardiovascular risk-marker improvements. These are research findings only — Peptides Calculator does not provide medical advice; consult a qualified healthcare professional before starting any peptide protocol.
What are the side effects of Dulaglutide?
Reported side effects of Dulaglutide include: Nausea, vomiting, diarrhea, or constipation, Abdominal pain or decreased appetite, Injection-site reactions, Rare: pancreatitis, gallbladder disease, Hypoglycemia when combined with insulin or sulfonylureas, Boxed warning (rodent): thyroid C-cell tumors; contraindicated with personal/family history of MTC or MEN2 in clinical use contexts. Always discuss potential side effects with a licensed healthcare provider before using any research peptide.