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Dulaglutide

GLP-1 Receptor Agonist (Long-acting)For research use only
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Dulaglutide is a long-acting GLP-1 receptor agonist composed of two GLP-1 analog chains fused to an IgG4 Fc fragment. In research settings it’s used to study gl…

Half-life

Approximately ~120 hours (~5 days)

Delivery

Once-weekly subcutaneous injection (prefilled pen formats in clinical use; dose and device vary by study/protocol).

Suggested dosage

Not specified

Usage

Investigated for improving glycemic control, reducing cardiometabolic risk markers, and modeling weight/appetite pathways via incretin signaling.

Mechanism of action

Activates GLP-1 receptors to enhance glucose-dependent insulin secretion, suppress inappropriate glucagon release, slow gastric emptying, and reduce appetite through central and peripheral pathways.

Benefits (4)

  • Improved fasting and postprandial glucose
  • Reduced A1c in type 2 diabetes models
  • Decreased appetite and body weight in study populations
  • Potential cardiovascular risk-marker improvements

Side effects (6)

  • Nausea, vomiting, diarrhea, or constipation
  • Abdominal pain or decreased appetite
  • Injection-site reactions
  • Rare: pancreatitis, gallbladder disease
  • Hypoglycemia when combined with insulin or sulfonylureas
  • Boxed warning (rodent): thyroid C-cell tumors; contraindicated with personal/family history of MTC or MEN2 in clinical use contexts
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