Peptide Library / Detail
5-Amino-1MQ
Half-life
Not well characterized
Delivery
Oral
Dosage
—
Research Use Only
All products listed are for laboratory research only — not for human consumption. By browsing, you acknowledge these terms.
Description
5-Amino-1MQ is a potent and selective small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that methylates nicotinamide to 1-methylnicotinamide, thereby modulating NAD⁺ metabolism and influencing energy expenditure and adiposity.
Usage
Used in research to study NNMT activity, NAD⁺ salvage pathways, obesity, type 2 diabetes, and metabolic regulation.
Mechanism of Action
Binds to the active site of NNMT, preventing methylation of nicotinamide, which leads to increased intracellular NAD⁺ levels, enhanced mitochondrial function, and reduced lipogenesis.
Benefits(4)
- Increased NAD⁺ levels
- Enhanced mitochondrial function
- Reduced adiposity in diet-induced obesity models
- Improved glucose tolerance
Side Effects(2)
- Not well characterized in humans
- Potential off-target effects at high doses