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5-Amino-1MQ
Nicotinamide N-methyltransferase Inhibitor
5-Amino-1MQ is a potent and selective small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that methylates nicotinamide to 1-methylnicotinamide, thereby modulating NAD⁺ metabolism and influencing energy expenditure and adiposity.
Usage:
Used in research to study NNMT activity, NAD⁺ salvage pathways, obesity, type 2 diabetes, and metabolic regulation.
Mechanism of Action:
Binds to the active site of NNMT, preventing methylation of nicotinamide, which leads to increased intracellular NAD⁺ levels, enhanced mitochondrial function, and reduced lipogenesis.
Benefits:
- Increased NAD⁺ levels
- Enhanced mitochondrial function
- Reduced adiposity in diet-induced obesity models
- Improved glucose tolerance
Side Effects:
- Not well characterized in humans
- Potential off-target effects at high doses
Suggested Dosage:
Not specified
Half-life: Not well characterized
Delivery: Oral