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5-Amino-1MQ

Nicotinamide N-methyltransferase InhibitorFor research use only
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5-Amino-1MQ is a potent and selective small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that methylates nicotinamide to 1-methylnic…

Half-life

Not well characterized

Delivery

Oral

Suggested dosage

Not specified

Usage

Used in research to study NNMT activity, NAD⁺ salvage pathways, obesity, type 2 diabetes, and metabolic regulation.

Mechanism of action

Binds to the active site of NNMT, preventing methylation of nicotinamide, which leads to increased intracellular NAD⁺ levels, enhanced mitochondrial function, and reduced lipogenesis.

Benefits (4)

  • Increased NAD⁺ levels
  • Enhanced mitochondrial function
  • Reduced adiposity in diet-induced obesity models
  • Improved glucose tolerance

Side effects (2)

  • Not well characterized in humans
  • Potential off-target effects at high doses
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