Peptide Library / Detail
5-Amino-1MQ
Half-life
Not well characterized
Delivery
Oral
Dosage
—
Research Use Only
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Description
5-Amino-1MQ is a potent and selective small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that methylates nicotinamide to 1-methylnicotinamide, thereby modulating NAD⁺ metabolism and influencing energy expenditure and adiposity.
Usage
Used in research to study NNMT activity, NAD⁺ salvage pathways, obesity, type 2 diabetes, and metabolic regulation.
Mechanism of Action
Binds to the active site of NNMT, preventing methylation of nicotinamide, which leads to increased intracellular NAD⁺ levels, enhanced mitochondrial function, and reduced lipogenesis.
Benefits(4)
- Increased NAD⁺ levels
- Enhanced mitochondrial function
- Reduced adiposity in diet-induced obesity models
- Improved glucose tolerance
Side Effects(2)
- Not well characterized in humans
- Potential off-target effects at high doses
5-Amino-1MQ — frequently asked questions
What is 5-Amino-1MQ?
5-Amino-1MQ is a potent and selective small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that methylates nicotinamide to 1-methylnicotinamide, thereby modulating NAD⁺ metabolism and influencing energy expenditure and adiposity.
What is the half-life of 5-Amino-1MQ?
5-Amino-1MQ has an approximate half-life of Not well characterized. The half-life determines how often you need to inject to maintain steady blood levels — use the Peptides Calculator half-life calculator to plot your specific dosing schedule and see the decay curve.
How is 5-Amino-1MQ administered?
5-Amino-1MQ is typically delivered via oral. The Peptides Calculator app helps you reconstitute the vial with bacteriostatic water, calculate your exact dose in syringe units, and track each injection.
How does 5-Amino-1MQ work?
Binds to the active site of NNMT, preventing methylation of nicotinamide, which leads to increased intracellular NAD⁺ levels, enhanced mitochondrial function, and reduced lipogenesis.
What are the researched benefits of 5-Amino-1MQ?
Studied benefits of 5-Amino-1MQ include: Increased NAD⁺ levels, Enhanced mitochondrial function, Reduced adiposity in diet-induced obesity models, Improved glucose tolerance. These are research findings only — Peptides Calculator does not provide medical advice; consult a qualified healthcare professional before starting any peptide protocol.
What are the side effects of 5-Amino-1MQ?
Reported side effects of 5-Amino-1MQ include: Not well characterized in humans, Potential off-target effects at high doses. Always discuss potential side effects with a licensed healthcare provider before using any research peptide.