Peptide Library / Detail
Leuprolide
Half-life
3-4 hours (immediate release); extended for depot formulations (1-4 months)
Delivery
Subcutaneous or intramuscular injection
Dosage
—
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Description
Leuprolide is a synthetic nonapeptide analog of gonadotropin-releasing hormone (GnRH) that acts as a potent agonist. It is widely used in clinical medicine to regulate sex hormone production by initially stimulating and then suppressing pituitary gonadotropin secretion. Leuprolide has established therapeutic applications in hormone-sensitive conditions including prostate cancer, endometriosis, and precocious puberty.
Usage
Clinical dosing varies by indication and formulation. Depot injections typically range from 3.75 mg to 22.5 mg administered monthly to every 3-6 months. Daily subcutaneous injections of 1 mg may be used for certain conditions. Treatment duration depends on the specific therapeutic goal and is determined by healthcare providers.
Mechanism of Action
Leuprolide initially stimulates GnRH receptors in the pituitary gland, causing a transient increase in luteinizing hormone (LH) and follicle-stimulating hormone (FSH). With continuous administration, it causes receptor downregulation and desensitization, leading to suppression of gonadotropin secretion and subsequent reduction in testosterone and estrogen production to castration or menopausal levels within 2-4 weeks.
Benefits(6)
- Suppression of testosterone in androgen-dependent prostate cancer
- Reduction of endometriosis symptoms and lesion size
- Management of precocious puberty in children
- Treatment of uterine fibroids and associated symptoms
- Reduction of ovarian hormone production in hormone-sensitive conditions
- Improvement in pain and dysmenorrhea associated with endometriosis
Side Effects(8)
- Hot flashes and sweating
- Decreased libido and sexual dysfunction
- Bone density loss with prolonged use
- Initial tumor flare in prostate cancer patients
- Mood changes and depression
- Headache and dizziness
- Injection site reactions
- Fatigue and weakness
Leuprolide — frequently asked questions
What is Leuprolide?
Leuprolide is a synthetic nonapeptide analog of gonadotropin-releasing hormone (GnRH) that acts as a potent agonist. It is widely used in clinical medicine to regulate sex hormone production by initially stimulating and then suppressing pituitary gonadotropin secretion. Leuprolide has established therapeutic applications in hormone-sensitive conditions including prostate cancer, endometriosis, and precocious puberty.
What is the half-life of Leuprolide?
Leuprolide has an approximate half-life of 3-4 hours (immediate release); extended for depot formulations (1-4 months). The half-life determines how often you need to inject to maintain steady blood levels — use the Peptides Calculator half-life calculator to plot your specific dosing schedule and see the decay curve.
How is Leuprolide administered?
Leuprolide is typically delivered via subcutaneous or intramuscular injection. The Peptides Calculator app helps you reconstitute the vial with bacteriostatic water, calculate your exact dose in syringe units, and track each injection.
How does Leuprolide work?
Leuprolide initially stimulates GnRH receptors in the pituitary gland, causing a transient increase in luteinizing hormone (LH) and follicle-stimulating hormone (FSH). With continuous administration, it causes receptor downregulation and desensitization, leading to suppression of gonadotropin secretion and subsequent reduction in testosterone and estrogen production to castration or menopausal levels within 2-4 weeks.
What are the researched benefits of Leuprolide?
Studied benefits of Leuprolide include: Suppression of testosterone in androgen-dependent prostate cancer, Reduction of endometriosis symptoms and lesion size, Management of precocious puberty in children, Treatment of uterine fibroids and associated symptoms, Reduction of ovarian hormone production in hormone-sensitive conditions, Improvement in pain and dysmenorrhea associated with endometriosis. These are research findings only — Peptides Calculator does not provide medical advice; consult a qualified healthcare professional before starting any peptide protocol.
What are the side effects of Leuprolide?
Reported side effects of Leuprolide include: Hot flashes and sweating, Decreased libido and sexual dysfunction, Bone density loss with prolonged use, Initial tumor flare in prostate cancer patients, Mood changes and depression, Headache and dizziness, Injection site reactions, Fatigue and weakness. Always discuss potential side effects with a licensed healthcare provider before using any research peptide.