Peptide Library / Detail
SS-31
Half-life
≈2 hours
Delivery
Subcutaneous or intravenous injection
Dosage
—
Research Use Only
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Description
SS-31 (also known as Elamipretide or Bendavia) is a synthetic tetrapeptide that selectively targets cardiolipin on the inner mitochondrial membrane to improve mitochondrial function and reduce oxidative stress.
Usage
Used in research on mitochondrial dysfunction, ischemia-reperfusion injury, heart failure, neurodegenerative diseases, and age-related decline in bioenergetics.
Mechanism of Action
Binds to cardiolipin in the inner mitochondrial membrane, stabilizing cristae structure, enhancing electron transport chain efficiency, reducing reactive oxygen species production, and preventing cytochrome c peroxidase activity.
Benefits(5)
- Improved mitochondrial bioenergetics
- Reduced reactive oxygen species (ROS) production
- Protection against ischemia-reperfusion injury
- Improved cardiac and skeletal muscle function
- Neuroprotective effects in models of neurodegeneration
Side Effects(4)
- Injection-site reactions
- Nausea
- Headache
- Possible mild hypotension