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SS-31
Mitochondria-Targeted Peptide
SS-31 (also known as Elamipretide or Bendavia) is a synthetic tetrapeptide that selectively targets cardiolipin on the inner mitochondrial membrane to improve mitochondrial function and reduce oxidative stress.
Usage:
Used in research on mitochondrial dysfunction, ischemia-reperfusion injury, heart failure, neurodegenerative diseases, and age-related decline in bioenergetics.
Mechanism of Action:
Binds to cardiolipin in the inner mitochondrial membrane, stabilizing cristae structure, enhancing electron transport chain efficiency, reducing reactive oxygen species production, and preventing cytochrome c peroxidase activity.
Benefits:
- Improved mitochondrial bioenergetics
- Reduced reactive oxygen species (ROS) production
- Protection against ischemia-reperfusion injury
- Improved cardiac and skeletal muscle function
- Neuroprotective effects in models of neurodegeneration
Side Effects:
- Injection-site reactions
- Nausea
- Headache
- Possible mild hypotension
Suggested Dosage:
Not specified
Half-life: ≈2 hours
Delivery: Subcutaneous or intravenous injection