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Melanotan 1 (MT-1 / Afamelanotide)

Alpha-MSH Analog (MC1R-Selective)For research use only
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Melanotan 1 (afamelanotide) is a synthetic analog of alpha-melanocyte–stimulating hormone that preferentially activates MC1R to increase eumelanin production an…

Half-life

Approximately 30–60 minutes (systemic peptide); depot/implant formulations provide prolonged exposure (days).

Delivery

Subcutaneous injection in research settings; clinical use includes controlled-release subcutaneous implant.

Suggested dosage

Not specified

Usage

Studied for sunless tanning, reduction of UV-induced DNA damage, and photoprotection (e.g., erythropoietic protoporphyria models).

Mechanism of action

Agonizes melanocortin-1 receptors on melanocytes, upregulating cAMP/PKA signaling to enhance melanogenesis (eumelanin), increase melanosome transfer, and improve cutaneous photoprotection.

Benefits (4)

  • Increases skin pigmentation (eumelanin)
  • Enhances photoprotection and reduces UV sensitivity
  • May decrease UV-induced erythema/DNA damage
  • Lower incidence of nausea vs. MT-2 in many reports

Side effects (5)

  • Flushing or facial warmth
  • Headache or mild nausea
  • Injection-site irritation
  • Freckle/mole darkening and hyperpigmentation
  • Rare: increased blood pressure or fatigue
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