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Vial

FOX04-DRI (10 mg)

Senolytic PeptideFor research use only
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FOX04‑DRI (Retro‑Inverso) is a synthetic peptide designed to interfere with the FOXO4/p53 interaction, enabling selective induction of apoptosis in senescent ce…

Half-life

Prolonged compared to native FOXO4 peptide (due to retro‑inverso design)

Delivery

Subcutaneous injection (after reconstitution in bacteriostatic water or suitable solvent)

Suggested dosage

Not specified

Usage

Used in research to remove senescent cells and study aging, tissue regeneration, insulin signaling, and cell cycle control.

Mechanism of action

Acts as a cell‑penetrating peptide that disrupts FOXO4 binding to p53, freeing p53 to induce apoptosis in senescent cells.

Benefits (4)

  • Selective clearance of senescent cells
  • Improved organ and tissue function
  • Reduced aging‑related inflammatory signaling
  • Enhanced insulin sensitivity and metabolic outcomes

Side effects (2)

  • Limited human safety data
  • Potential off‑target effects in non‑senescent cells
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