Peptide Library / Detail
Thymulin
Half-life
Approximately 30-60 minutes
Delivery
Subcutaneous or intravenous injection
Dosage
—
Research Use Only
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Description
Thymulin is a zinc-dependent nonapeptide hormone secreted by thymic epithelial cells that plays a crucial role in T cell maturation and immune system regulation. It acts as a key mediator of thymic function, influencing both cellular and humoral immunity. Research has demonstrated its potential therapeutic applications in immune deficiency states, autoimmune conditions, and neurodegenerative diseases.
Usage
Research protocols typically involve subcutaneous or intravenous administration at doses ranging from 50-500 mcg, administered 1-3 times weekly. Zinc supplementation is often recommended concurrently due to thymulin's zinc-dependent activity. Treatment duration in studies varies from several weeks to months depending on the condition being investigated.
Mechanism of Action
Thymulin functions as an endocrine messenger that modulates T lymphocyte differentiation and maturation in the thymus. It requires zinc for biological activity, forming a zinc-thymulin complex that interacts with specific receptors on T cells. The peptide influences cytokine production, enhances natural killer cell activity, and regulates immune cell trafficking. Recent research indicates it may also protect the blood-brain barrier and modulate inflammatory responses through effects on multiple cellular pathways.
Benefits(8)
- Promotes T cell maturation and differentiation in the thymus
- Enhances immune system function and cellular immunity
- Supports blood-brain barrier integrity in neuroinflammatory conditions
- May reduce thymic atrophy associated with zinc deficiency
- Modulates inflammatory cytokine responses
- Potential neuroprotective effects in autoimmune neurological conditions
- Supports normal immune surveillance against abnormal cells
- May help normalize T cell maturation processes in immunodeficiency states
Side Effects(6)
- Local injection site reactions (redness, swelling)
- Potential allergic reactions in sensitive individuals
- Transient flu-like symptoms during initial administration
- Possible immune system overstimulation if improperly dosed
- Interactions with zinc metabolism and homeostasis
- Limited long-term safety data in humans