Peptide Library / Detail
Testagen
Half-life
Not definitively established in humans; likely short (minutes to hours) given tripeptide structure
Delivery
Subcutaneous or intramuscular injection in research settings
Dosage
—
Research Use Only
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Description
Testagen is a short tripeptide (Lys-Glu-Asp) classified as a bioregulatory peptide that has been studied for its cellular penetration properties and potential tissue-protective effects. Research has demonstrated its ability to penetrate cell nuclei and interact with DNA, suggesting regulatory functions at the genomic level. It belongs to a class of short peptides investigated for their role in cellular signaling and homeostasis.
Usage
Research protocols typically involve administration at microgram to low milligram doses, though specific human dosing parameters remain under investigation. Studies have utilized subcutaneous or intramuscular routes in experimental models. Timing and frequency protocols vary based on research objectives, with some studies examining acute cellular effects and others investigating longer-term regulatory impacts.
Mechanism of Action
Testagen demonstrates nuclear penetration capability in mammalian cells, allowing direct interaction with deoxyribooligonucleotides and DNA sequences as confirmed by fluorescence-labeled peptide studies (Fedoreyeva et al., 2011). The peptide's Lys-Glu-Asp sequence enables specific binding interactions with nucleic acids, potentially influencing gene expression and cellular regulatory pathways. Additionally, the peptide exhibits surface interaction properties that may contribute to cellular membrane dynamics and protection mechanisms.
Benefits(5)
- Nuclear penetration allowing potential genomic-level regulation
- Specific DNA and oligonucleotide binding capability
- May support cellular homeostasis and regulation
- Potential tissue-protective properties
- Investigated for bioregulatory effects on cellular aging processes
Side Effects(5)
- Limited human safety data available
- Potential immunogenic responses to exogenous peptides
- Injection site reactions possible with parenteral administration
- Unknown long-term effects on genomic regulation
- Interactions with endogenous regulatory pathways not fully characterized