Peptide Library / Detail
Humanin
Half-life
Approximately 30-60 minutes (varies by delivery method and formulation)
Delivery
Subcutaneous or intravenous injection in research settings; synthetic analogs and modified forms under development for improved stability
Dosage
—
Research Use Only
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Description
Humanin is a naturally occurring mitochondrial-derived peptide (MDP) consisting of 24 amino acids that plays a crucial role in cellular protection and metabolic regulation. It is encoded within the mitochondrial genome and acts as a cytoprotective factor against oxidative stress, inflammation, and cellular aging. Humanin has emerged as a promising therapeutic target for metabolic disorders, neurodegenerative diseases, and age-related conditions.
Usage
Humanin is primarily studied in research settings with dosing protocols varying based on the condition and delivery method. Typical research protocols involve subcutaneous or intravenous administration with dosages ranging from micrograms to milligrams per kilogram body weight. In animal studies, daily or intermittent dosing regimens have been employed. Clinical research in humans is still in early stages, with optimal dosing and frequency yet to be established.
Mechanism of Action
Humanin exerts its cytoprotective effects by binding to multiple cellular receptors, including the CNTFR/WSX-1/gp130 trimeric receptor complex and FPRL1/2. It activates survival signaling pathways such as PI3K/AKT and STAT3, while inhibiting pro-apoptotic proteins like BAX and Bid. Humanin reduces oxidative stress by enhancing mitochondrial function, decreasing reactive oxygen species production, and suppressing inflammatory cascades including NF-κB activation. It also modulates cellular metabolism and insulin sensitivity.
Benefits(8)
- Protects against oxidative stress and mitochondrial dysfunction
- Improves metabolic health and insulin sensitivity in liver and other tissues
- Supports bone health and reduces glucocorticoid-induced bone loss
- Enhances cellular survival under hypoxic and ischemic conditions
- Reduces age-related cellular inflammation (inflammaging)
- May improve semen quality and reproductive function
- Shows potential as a biomarker for neurodegenerative diseases including Alzheimer's
- Demonstrates anti-apoptotic properties in various cell types
Side Effects(5)
- Limited human safety data available as research is in early stages
- Potential immune system modulation effects require further study
- Long-term effects of exogenous administration unknown
- Possible interactions with metabolic signaling pathways
- Safety profile in various disease states not fully characterized