Peptide Library / Detail
Cortagen
Half-life
Not well established in human studies
Delivery
Subcutaneous or intramuscular injection
Dosage
—
Research Use Only
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Description
Cortagen is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from brain cortex tissue that acts as a bioregulator with neuroprotective and immunomodulatory properties. Research indicates it influences gene expression, particularly in cardiovascular and neural tissues, while demonstrating effects on immune function and cellular aging processes. It belongs to a class of short peptides that work through epigenetic mechanisms to modulate tissue-specific function.
Usage
Research protocols typically involve subcutaneous or intramuscular administration. Dosing in experimental studies has ranged from micromolar concentrations in vitro to milligram quantities in animal models, administered over periods of 10-30 days. Timing and frequency vary by research objective, with some studies using daily administration while others employ less frequent dosing schedules.
Mechanism of Action
Cortagen operates through epigenetic modification of chromatin structure, influencing gene expression without altering DNA sequences. It modulates IL-2 mRNA synthesis in hypothalamic structures and affects lymphocyte chromatin in aging subjects. Microarray analysis has shown it regulates multiple gene pathways in cardiac tissue. The peptide demonstrates antioxidant properties by influencing free-radical processes and provides neuroprotection during ischemic conditions, potentially through preconditioning mechanisms.
Benefits(7)
- Neuroprotection during cerebral ischemia and chronic brain ischemia
- Modulation of immune function through lymphocyte activation
- Epigenetic regulation of gene expression in aging tissues
- Reduction of oxidative stress and free-radical damage
- Enhancement of IL-2 synthesis and immune signaling
- Improvement of metabolic and functional parameters in ischemic brain tissue
- Support of hemostasis and immune parameters in aging models
Side Effects(5)
- Limited human safety data available
- Potential injection site reactions
- Unknown long-term effects in humans
- Possible immunomodulatory effects requiring monitoring
- Interactions with other peptide bioregulators not fully characterized